A Cases of Xanthogranulomatous Pyelonephritis in Children / 대한비뇨기과학회지

Xanthogranulomatous pyelonephritis is an uncommon form of chronic bacterial infection of the kidney that may occur at any age but is most often seen in middle-aged or older women. Xanthogranulomatous pyelonephritis in children is very rare. We report a 2-year-4-month-old male hospitalized with complaints of palpable abdominal mass. Excretory urography, abdominal sonogram, abdominal computed tomogram showed hydronephrosis with right renal stones and ureteropelvic junction obstruction. It was treated with right nephrectomy. Pathologic findings revealed xanthogranulomatous pyelonephritis postoperatively. This case is a xanthogranulomatous pyelonephritis occurred in the most youngest age in Korean literatures.

The Clinical Significance of Bosniak Classification in Cystic Renal Masses : Usefulness of Preoperative Computerized Tomography in Cystic Renal Masses / 대한비뇨기과학회지

To determine the usefulness of the Bosniak classification of cystic renal masses, the computed tomographic findings of 30 pathologically proven cystic renal masses were reviewed retrospectively. We categorized cystic renal masses utilizing the Bosniak classification without knowledge of the final pathologic diagnosis. There were 10 category I lesions, 3 category II lesions, 6 category III lesions and 11 category IV lesions. All category l and II lesions were benign. All category IV lesions were malignant. Among the 6 category III lesions, 5 were malignant. The other was benign lesion with hemorrhagic renal cyst. We concluded that computed tomography and Bosniak classification are useful in management of cystic renal masses.

A case of transitional cell carcinoma of bladder, metastasis to ovary / 대한비뇨기과학회지

The incidence of ovarian metastasis of transitional cell carcinoma is very rare and its prognosis appears to be poor. We have experienced a unique case of ovarian metastasis from transitional cell carcinoma of the bladder in 59 year old female whose complaint was palpable abdominal mass. The patient previously underwent partial cystectomy due to perforation during transurethral resection of the bladder tumor. During the course of evaluation, left distal ureteral tumor was identified with cystic abdominal mass. On exploration, the palpable abdominal mass was confirmed as ovarian mass. She eventually underwent left oophorectomy and distal ureterectomy. The final diagnosis was confirmed as metastatic ovarian transitional cell carcinoma.

An immunohistochemicl study of P-glycoprotein in transitional cell carcinoma / 대한비뇨기과학회지

Tumor cell resistance to cytotoxic drug is thought to be a major cause of failure in the chemotherapeutic treatment of malgnant tumors. Multidrug resistance (MDR) is associated with r expression of the MDRl gene encoding P-glycoproteintP-gp). an active efflux pump for various limphophilic compounds. P-gp was generally expressed in normal tissue and tumor. In our present investigation. we examined the expression of P-gp in human transitional cell carcinoma and normal tissue. 1. From April to June. 1992. 13 patients with transitional cell carcinoma(11 cases in bladder. cases in renal pelvis) and 5 specimens of normal urinary bladder tissue were used. 2. We stained these frozen tissue with JSB-1 (MONOSAN(R)) by immunehistochemistry. 3. The tissue sample was classified as weakly positive. moderately positive and strong positive respectively to the immunohistochemical staining under the light microgcopical observation. The weakly positive means that if the sample cell was stained with less than the fine reddish brown colored particles. The strong positive presents the cell nuclei was not seen by light microscopic examination because the cell was heavily stained with large reddish brown colored granules. In between weakly and strong positive was named as moderate positive. 4. 7 out of 13 transitional cell carcinoma showed Ash grade II,4 of this 7 belongs to moderately positive and the rest 3 of this 7 were strong positive class. All 6 cases of stage B, C, D transitional cell carcinoma belongs to moderate positive class. On the basis of the results, this study suggested that the normal bladder tissues and transitional cell carcinoma contain certain amount of P-gp. The author could conclude that there is no closerelation between the tissue staining classification.

Comparative study between cytogenetic analysis and flow cytometric analysis in transitional cell carcinoma of the urinary bladder / 대한비뇨기과학회지

Both cytogenetic analysis and flow cytometric analysis (FCM) are well known prognostic indicators in the transitional cell carcinoma (TCC) of the urinary bladder. To correlate results of the two methods, FCM cell DNA studies and cytogenetic analysis were performed concurrently on clinical samples from the twelve patients with TCC of urinary bladder and the cells taken from these comparisons were possible showed concordance between FCM and cytogenetics with respect to the presence or absence of aneuploidy. Among the four cases with discrepancies, three (27.2 % of all cases) showed peridiploid pattern by cytogenetic analysis and had tetraploid aneuploid DNA histograms. In one case with hyperdiploid pattern by cytogenetics (9.1 %) showed diploid on the nine patients with peridiploid pattern one has recurred. Also, two of the three patients with aneuploid pattern by cytogenetic study were recurred. In flow cytometric analysis, all of the nine patients with diploid pattern were not recurred. Whereas, of the nine cases of aneuploid patterns five were recurred. Although the number of samples were too small to compare the correlations statistically, our results indicate that these two methods are not related to each other in predicting the prognosis in transitional cell carcinoma of the urinary bladder.